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Premium Silicone Weighted Anal Plug - Large


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These comfortable weighted butt plugs hit hard and deep! Heavy Hitter Comfort Plugs are crafted for a fulfilling backdoor fill without the discomfort of larger toys - the round and tapered body inserts easily while the narrow neck flexible base move with your butt cheeks so you can play for extended sessions without discomfort.Made with premium, silky smooth silicone for a luxurious velvety texture your ass is gonna love! Phthalate free, non-porous, and body safe for a worry free anal experience - use with water based lubes only to prolong the life of your Heavy Hitter.Insert and feel the satisying weight of this comfy anal toy: The gratifying 9.2 ounce metal weight found in this Large Heavy Hitter provides a satisfying downward pull with your every movement, while also providing a solid core for you to squeeze on. Perfect for warming up the backdoor - plug your lovers booty and warm up their backdoor as you go about the home in preparation for the main anal event of the night!Measurements: Overall length 6 inches, bulb length 3.5 inches, neck length 1.8 inches, total insertable length 5.3 inches, bulb diameter 1.8 inches, base length 4.3 inchesBall Weight: 9.2 ouncesMaterials: Silicone and metalColor: Black

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Acquisition adds a market leader in affinity ligand discovery and development and strategically moves Repligen into affinity resin solutions for Gene Therapy.

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Advanced Chromatography System

Featuring Artesyn® innovation and engineering, the new system achieves higher recovery and faster, simpler batch change-overs.

  • Overmolded connections reduce leak potential
  • Dead leg minimizing valve locks
  • As fast as 30 minute batch changes
  • Up to 35% higher recovery

Artesyn® Chromatography Systems



Fully automate flat sheet tangential flow filtration (TFF) processes such as CFC/D/C up to 500 L with configurable hardware components that deliver an unparalleled combination of automation, configurability, simplicity and compliance.

Fluid Management Solutions

Fluid management is critical in upstream and downstream biopharmaceutical manufacturing processes. Repligen fluid management solutions include  custom and standard ProConnex® Flow Paths, molded components and tubing, bottles and containers, innovative valves, and process equipment.


Explore fluid management solutions

OPUS® column packing

in europe, for europe

Repligen is now the only supplier with column packing capabilities on two continents with the new OPUS® Manufacturing Center of Excellence in Breda, The Netherlands.​

Repligen Breda simplifies European supply chain logistics by enabling regional column packing. Global customers realize benefits of expanded manufacturing capacity for OPUS® Columns. ​

opus® EU manufacturing center of excellence

Recent Announcements

CTechFlowVPX® System

For in-line Process Analytics

Designed to meet the rigors of regulatory GMP requirements, the new CTech FlowVPX offers reliable real-time results with integrated ease for concentration measurements during every stage of the downstream GMP process.

Plug, Play, Walk Away

OMW! With XCell™

Small But Mighty

XCell ATF® 0.5L Scale-down

Process Intensification System

Designed for simplicity and engineered for precision, the new XCell™ Lab System integrates a modernized controller, intuitive software, and monitoring devices.

See how it works

NGL COVID-19 Spike Protein Affinity Resin for the

purification of covid-19 vaccines

Repligen introduces novel affinity resin for the purification of the SARS CoV-2 Spike Protein for vaccine development and manufacturing. NGL COVID-19 Spike Protein Affinity Resin binds the SARS-CoV-2 Spike Protein receptor binding domain (RBD) to yield exceptional purity in a single chromatography step. The resin is available in off-the shelf, pre-packed and pre-qualified OPUS® Columns for rapid implementation as well as in loose resin formats.

About NGL COVID-19 Spike Protein Affinity Resin                                    REquest a sample

COVID-19 Solutions

Repligen Solutions From Gene to Therapy

"The DNA of our company is absolutely around customer first. Listening to what our customers are doing, what their needs are, what their pain points are, touches every facet of what we do."

Tony Hunt, President and CEO        

Join the REpligen Team

With offices and facilities in multiple locations, we are always looking for smart, driven, and enthusiastic individuals to join our growing team.

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